A merging of Sanrio characters with the Cthulhu Mythos results in the webcomic Hello Cthulhu 
The character Maromi in Paranoia Agent is a pastiche of Hello Kitty.
On the episode "Thirty Minutes Over Tokyo" of the TV series The Simpsons, the family travels to Japan and passes by the Hello Kitty merchandise factory. The yowling noises from within suggest that they were made from real cats.
Hello Kitty made a guest appearance on an episode of Robot Chicken as a martial arts master.
In The Grim Adventures of Billy and Mandy, there is a Hello Kitty parody named Sassy Cat.
In the Futurama episode, Crimes of the Hot, a "Curious Pussycat" factory is seen in the background of a scene set in Kyoto. The logo is reminiscent of the Hello Kitty logo.
The band Goons of Doom created a song entitled "Hello Kitty", presumably relating to the character.
The Online Webcomic The Order of the Stick parodies Hello Kitty by creating a, presumably parallel, character in the world in which the comic takes place. This character is known as "Hello Goblin", and is seen on an umbrella that is carried by the Monster in the Dark.
On the episode "Make Love, Not Warcraft" of South Park, Butters states that he does not play World of Warcraft but rather the fictional game Hello Kitty Island Adventure.
The After Dark screensaver "Hall of Fame", which features several famous After Dark characters portrayed as anime characters, shows an image of Bad Dog that looks like Hello Kitty.
On the episode "No Man's Land" of Grey's Anatomy Izzie is wearing Hello Kitty panties. Meredith greets her with the words "Hello Kitty".
In the Too $hort song "Burn Rubber," Too $hort talks about pimping hoes, "Take your ass straight out, of Sin City. Wearin' all pink like Hello Kitty. Bringin back all C-notes and no fifties."
Dave Navarro performed a reunion concert with The Red Hot Chili Peppers as a homage to Hello Kitty, and played a Hello Kitty guitar given to him by Hello Kitty herself.
In the TV show Danny Phantom, the episode What You Want includes a film called 'Sayonara Pussycat', featuring a cat similar to Hello Kitty. Sayonara is Japanese for goodbye.
A shop of Warhammer 40,000 cover art parodies Hello Kitty's cheerful image, with the pronouncement "IN THE GRIM FUTURE OF HELLO KITTY THERE IS ONLY WAR".
Gaia Online features a plushie of a white cat called the Kiki Kitty Plushie, as well as a black version called Coco. The description reads that it is a plushie version of a fictional cartoon character, a parody of Hello Kitty. However, the item has evolved into a mascot in its own right, and is one of the most famous items in the game, and even appears on real life merchandise.
In the game Destroy All Humans! 2, if you scan a mind of a teenage Japanese female, the will sometimes mention a parody of Hello Kitty, 'Hiya Pussy'.
In Jon Stewart's book America: The Book, a page about Japan labels the Prime Minister and national flower with a Hello Kitty face.
In the Neopets website, the Plushie Angelpuss is based on Hello Kitty.
In the episode Itty Bitty Kitty of Brandy & Mr. Whiskers, Brandy's cat doll named "Itty Bitty Kitty" is a parody of Hello Kitty.